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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ITPKA All Species: 24.24
Human Site: S143 Identified Species: 53.33
UniProt: P23677 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P23677 NP_002211.1 461 51009 S143 D S E D D L L S D S E S R S R
Chimpanzee Pan troglodytes XP_001149577 401 45057 K104 A G E D V G Q K N H W Q K I R
Rhesus Macaque Macaca mulatta XP_001099176 645 70639 S327 D S E D D L L S D S E S R S R
Dog Lupus familis XP_544631 632 69191 S314 D S E D D L L S D S E S R S R
Cat Felis silvestris
Mouse Mus musculus Q8R071 459 50916 S141 D S E D D L L S D S E S R S R
Rat Rattus norvegicus P17105 459 50852 S141 D S E D D L L S D S E S R S R
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_990212 452 51079 S135 D S E D D V L S D T E C R S Q
Frog Xenopus laevis NP_001088157 516 58252 G197 E S E D D F G G S D M E P N G
Zebra Danio Brachydanio rerio Q5TZ07 288 31266 G21 G S V P C P G G N G R Y E F I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572875 669 73198 S307 D L S S E W D S D V S T S A A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795627 356 40840 N89 Q L A G H Q G N F K A G E Y G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 86.5 70.5 68.6 N.A. 93.2 93.4 N.A. N.A. 64.6 44.5 21 N.A. 37.6 N.A. N.A. 42.7
Protein Similarity: 100 86.5 70.8 69.7 N.A. 96 96 N.A. N.A. 74.6 57.9 32.9 N.A. 46.6 N.A. N.A. 53.8
P-Site Identity: 100 20 100 100 N.A. 100 100 N.A. N.A. 73.3 26.6 6.6 N.A. 20 N.A. N.A. 0
P-Site Similarity: 100 33.3 100 100 N.A. 100 100 N.A. N.A. 93.3 40 13.3 N.A. 40 N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 0 0 0 0 0 0 0 10 0 0 10 10 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 64 0 0 73 64 0 10 0 64 10 0 0 0 0 0 % D
% Glu: 10 0 73 0 10 0 0 0 0 0 55 10 19 0 0 % E
% Phe: 0 0 0 0 0 10 0 0 10 0 0 0 0 10 0 % F
% Gly: 10 10 0 10 0 10 28 19 0 10 0 10 0 0 19 % G
% His: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 % I
% Lys: 0 0 0 0 0 0 0 10 0 10 0 0 10 0 0 % K
% Leu: 0 19 0 0 0 46 55 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 19 0 0 0 0 10 0 % N
% Pro: 0 0 0 10 0 10 0 0 0 0 0 0 10 0 0 % P
% Gln: 10 0 0 0 0 10 10 0 0 0 0 10 0 0 10 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 10 0 55 0 55 % R
% Ser: 0 73 10 10 0 0 0 64 10 46 10 46 10 55 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 10 0 10 0 0 0 % T
% Val: 0 0 10 0 10 10 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 10 0 0 0 0 10 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 10 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _